Mutant receptors and their use in a nuclear receptor-based...

Details Mutant receptors and their use in a nuclear receptor-based... Mutant receptors and their use in a nuclear receptor-based...

A - Human Necessities

01

K

A01K 67/00 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 1/00 (2006.01) C12N 5/02 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2563521

This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell- based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

Cette invention traite du domaine de la biotechnologie ou du génie génétique. Plus particulièrement, cette invention traite du domaine de l'expression génétique. Plus particulièrement, cette invention traite de nouveaux récepteurs mutants de substitution et de leur utilisation dans un système d'expression de gène inductible basé sur un récepteur nucléaire et de méthodes de modulation de l'expression d'un gène dans une cellule hôte pour des applications comme la thérapie génique, la production à grande échelle de protéines et d'anticorps, les essais de criblage à haut débit basées sur les cellules, les génomiques fonctionnelles et la régulation des traits dans les organismes transgéniques.

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