Mutant simplex virus for treating unwanted...

Details Mutant simplex virus for treating unwanted... Mutant simplex virus for treating unwanted...

A - Human Necessities

61

K

A61K 39/245 (2006.01) A61K 31/00 (2006.01) A61K 35/76 (2006.01) C07K 14/035 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2382998

The present invention relates to pharmaceutical compositions, kits, and methods of use thereof, comprising, a mutant human herpes simplex-type 1 virus, which is cytopathic to susceptible hyperproliferative cells, such as neoplastic cells. Preferably, the virus does not produce a fully functionally active wild-type ICP0 polypeptide coded for the IE gene 1.

L'invention concerne des compositions pharmaceutiques, des trousses et des procédés d'utilisation de ces compositions. Les compositions pharmaceutiques selon l'invention comprennent un virus herpès simplex humain de type 1 mutant, cytopathique envers des cellules susceptibles d'hyperprolifération, telles que des cellules néoplastiques. De préférence, le virus ne produit pas de polypeptide ICP0 de type sauvage à action fonctionnelle complète codé par le gène IE 1.

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