Mutant t-pa with kringle replacement

Details Mutant t-pa with kringle replacement Mutant t-pa with kringle replacement

C - Chemistry, Metallurgy

12

N

195/1.22, 195/1.

C12N 9/72 (2006.01) A61K 38/49 (2006.01) C12N 15/12 (2006.01) C12N 15/66 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341447

Tissue plasminogen activator analogs exhibiting greater specificity for fibrin than native t-PA are disclosed. The analogs include the K1 domain of native t-PA replaced with another kringle domain mediating the binding of the analog to fibrin. The kringle contains six cysteine residues. The t-PA analogs may further include a variety of substitutions and modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.

568719

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