Mutant timp-3

Details Mutant timp-3 Mutant timp-3

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) C07K 14/81 (2006.01) C12P 21/02 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2617138

A mutant TIMP-3 (Tissue Inhibitor of MetalloProteinase-3) polypeptide wherein an additional residue or residues, for example an alanine residue, precedes the N-terrninal residue of the TIMP -3 polypeptide; or wherein the residue corresponding to Threonine2 of TIMP-3 is mutated to Glycine. Such a mutant is considered to retain activity as an inhibitor of ADAMs, such as TACE, ADAMTS-4 and ADAMTS-5, but to have reduced activity as an inhibitor of MMPs.

L'invention concerne un polypeptide TIMP-3 (inhibiteur tissulaire de métalloprotéinases 3) mutant, dans lequel un résidu ou des résidus supplémentaires, par exemple un résidu d'alanine, précède le résidu N-terminal du polypeptide TIMP-3 ; ou dans lequel le résidu correspondant à la thréonine2 de TIMP-3 est mutée en glycine. Ledit mutant est considéré pour conserver son activité en tant qu'inhibiteur d'ADAM, tels que TACE, ADAMTS-4 et ADAMTS-5, mais pour avoir une activité réduite en tant qu'inhibiteur de MMP.

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