Mutant vesicular stomatitis viruses and use thereof

Details Mutant vesicular stomatitis viruses and use thereof Mutant vesicular stomatitis viruses and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/205 (2006.01) C07K 14/145 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2520279

The present invention provides mutant viruses with a decreased ability to block nuclear transport of mRNA or protein in an infected cell which are attenuated in vivo. The mutant viruses of the present invention may also be capable of triggering the anti-viral systems of normal host cells while remaining sensitive to the effects of these systems. The present invention further provides for the use of the mutant viruses in a range of applications including, but not limited to, as therapeutics for the treatment of cancer and infections, as vaccines and adjuvants, as viral vectors, and as oncolytic and cytolytic agents for the selective lysis of malignant or infected cells.

La présente invention concerne des virus mutants ayant une aptitude réduite à bloquer le transport nucléaire de l'ARNm ou de protéine dans une cellule infectée, lesquels sont atténués <i>in vivo</i>. Le virus mutant de la présente invention peut également permettre de déclencher les systèmes anti-viraux de cellules hôtes normales tout en demeurant sensibles aux effets de ces systèmes. La présente invention concerne l'utilisation du virus mutant dans une gamme d'applications, à savoir de manière non exhaustive, comme thérapeutiques pour le traitement du cancer et d'infections, comme vaccins et adjuvants, comme vecteurs viraux et comme agents oncolytiques et cytolytiques pour la lyse sélective de cellules malignes ou infectées.

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