C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A01K 67/027 (2006.01) C12N 9/78 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2757178
The invention provides functional mutants of activation-induced cytidine deaminase (AID) protein that have increased activity as compared to a wild-type AID protein. The invention also provides nucleic acids encoding the functional AID mutants, and vectors and cells comprising the nucleic acids. The invention further provides methods of using the functional mutant AID proteins.
L'invention concerne des mutants fonctionnels de protéine cytidine désaminase induite par activation (AID) qui présentent une activité accrue par rapport à une protéine AID sauvage. L'invention concerne également des acides nucléiques codant les mutants d'AID fonctionnels, et des vecteurs et des cellules comprenant les acides nucléiques. L'invention concerne en outre des procédés d'utilisation des protéines d'AID mutantes fonctionnelles.
Neuberger Michael
Rada Cristina
Wang Meng
Yang Zizhen
Medical Research Council
Ridout & Maybee Llp
LandOfFree
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