C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2551008
It is intended to provide mutants of anti-CD40 antibody, which is expected as therapeutically efficacious, having been optimized as a drug by lowering the ADCC and CDC activities thereof. Namely, an agonistic anti-CD40 monoclonal antibody mutant in which at least the hinge region is a hinge region originating in human IgG2 and which has a mutation and/or a substitution of one or more amino acids causing lowering in the ADCC and/or CDC activities in the constant region; and an antagonistic anti-CD40 antibody mutant which has at least one mutation and/or substitution causing lowering in the ADCC and/or CDC activities in the constant region.
L'invention concerne des mutants d'un anticorps anti-CD40, dont on attend une efficacité thérapeutique, après optimisation comme médicament par abaissement des activités ADCC et CDC. L'invention concerne notamment un mutant agoniste de l'anticorps monoclonal anti-CD40, ce mutant ayant au moins la région charnière originaire du IgG2 humain et présentant une mutation et/ou une substitution d'un ou de plusieurs aminoacides provoquant l'abaissement des activités ADCC et/ou CDC dans la région constante. La présente invention porte également sur un mutant antagoniste de l'anticorps anti-CD40, présentant au moins une mutation et/ou une substitution provoquant l'abaissement des activités ADCC et/ou CDC dans la région constante.
Hirano Aki
Kitagawa Yoshinori
Miura Toru
Takahashi Nobuaki
Kirin Beer Kabushiki Kaisha
Kyowa Hakko Kirin Co. Ltd.
Smart & Biggar
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