C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/33 (2006.01) A61K 38/16 (2006.01) A61K 39/02 (2006.01) A61K 39/09 (2006.01) C07K 14/195 (2006.01) C07K 14/315 (2006.01) C07K 14/32 (2006.01)
Patent
CA 2683748
Mutants of cholesterol-dependent cytolysins comprising at least one amino acid substitution in at least one of Loop 1, Loop 2, or Loop 3 of Domain 4, nucleic acids encoding such polypeptide mutants, and compositions and vaccines comprising such polypeptide mutants.
La présente invention concerne des mutants de cytolysines dépendantes du cholestérol. Lesdits mutants comprennent au moins une substitution d'acide aminé dans au moins l'une des boucles 1, 2 ou 3 du domaine 4, des acides nucléiques codant pour de tels mutants polypeptidiques, et des compositions et des vaccins comprenant de tels mutants polypeptidiques.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Board Of Regents Of The University Of Oklahoma
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