Mutants of desoxycytidine kinase having extended enzymatic...

Details Mutants of desoxycytidine kinase having extended enzymatic... Mutants of desoxycytidine kinase having extended enzymatic...

C - Chemistry, Metallurgy

12

N

C12N 15/01 (2006.01) C12N 9/12 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2444026

The invention relates to a method for artificial in vivo evolution of proteins, said method making it possible to bring about the evolution of a protein X by complementation of a relative protein Y,X and Y both belonging to the same class of enzyme commission (EC) nomenclature or belonging to related classes. The mutants D133E and R104Q of desoxycytidine kinase (DCK) were obtained; both of said mutations result in acquisition of thymidine kinase activity by DCK.

La présente invention se rapporte à un procédé d'évolution artificielle in vivo de protéines, ledit procédé permettant de faire évolue une protéine X par complémentation d'une protéine apparentée Y, X et Y appartenant tous deux à la même classe de la nomenclature enzymatique EC ou à des classes voisines. Les mutants D133E et R104Q de la désoxycytidine kinase (DCK) ont été obtenus, chacune de ces mutations conférant l'acquisition de l'activité thymidine kinase par DCK.

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