C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 45/00 (2006.01) C07K 16/00 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2494115
The present invention generally relates to mutant IgE proteins. Specifically, the present invention relates to modified IgE proteins that have reduced flexibility in their heavy chains in comparison to unmodified IgE proteins and are, as a result, constrained in a particular conformational state. The present invention also relates to three-dimensional models of IgE glycosylation mutants. The present invention also relates to the use of proteins of the instant invention to produce and isolate compounds that will inhibit the binding of IgE protein to Fc.epsilon.Rl or Fc.epsilon.Rl.alpha.. Also included in the present invention are nucleic acid molecules encoding proteins of the instant invention. Also included are compounds which inhibit the binding of IgE to its receptor. The present invention also includes therapeutic compositions and kits comprising proteins and/or compounds of the instant invention as well as methods of treating an animal using such compositions and kits.
Mutants de protéines IgE, en particulier protéines IgE modifiées qui possèdent une souplesse réduite dans leur chaîne lourde, comparées aux protéines IgE non modifiées, et qui sont, par conséquent, contraintes dans un état conformationel particulier. La présente invention concerne également des modèles en trois dimensions de mutants obtenus par glycosylation d'IgE. Elle concerne aussi l'utilisation de protéines selon la présente invention pour produire et isoler des composés qui inhibent la liaison de la protéine IgE à FceRI ou FceRI.alpha.. Elle concerne encore des molécules d'acide nucléique codant les protéines selon la présente invention, des composés qui inhibent la liaison de IgE à son récepteur, des compositions et kits thérapeutiques comportant des protéines et / ou composés selon la présente invention, ainsi que des méthodes de traitement d'un animal à l'aide de ces compositions et kits.
Jardetzky Theodore S.
Wurzburg Beth A.
Jardetzky Theodore S.
Johnson Ernest Peter
Northwestern University
Wurzburg Beth A.
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