Mutants of il-16, processes for their production, and their use

Details Mutants of il-16, processes for their production, and their use Mutants of il-16, processes for their production, and their use

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2320624

A nucleic acid, which can be used to express an IL-16 mutant in a prokaryotic or eukaryotic host cell, wherein the said nucleic acid codes for a polypeptide with an amino acid sequence beginning with amino acids 1-5 and ending with amino acids 93-107 of SEQ ID NO:2, is suitable for producing IL-16 mutants with improved activity.

L'invention porte sur un acide nucléique qui peut être utilisé pour exprimer un mutant d'IL-16 (Interleukine-16) dans une cellule hôte procaryotique ou eucaryotique. Cet acide nucléique code pour un polypeptide avec une séquence d'acides aminés commençant par les acides aminés 1 à 5 et se terminant par les acides aminés 93 à 107 du NO ID SEQ: 2, et est approprié pour produire des mutants d'IL-16 à activité améliorée.

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