C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) C07K 16/40 (2006.01) C12N 9/50 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/535 (2006.01)
Patent
CA 2353314
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutant comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, is described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Furthermore, diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
Becker Margret
Feussner Annette
Lang Wiegand
Muth-Naumann Gudrun
Nerlich Claudia
Aventis Behring Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Csl Behring Gmbh
LandOfFree
Mutants of the factor vii-activating protease and detection... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mutants of the factor vii-activating protease and detection..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutants of the factor vii-activating protease and detection... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1565836