C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/46 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2273080
The invention concerns a purified polypeptide corresponding to a mutated form of the soluble LAG-3 protein or of one of its fragments comprising the extra-cellular domain D1 and D2.
Polypeptide purifié d'une forme mutée de la protéine LAG-3 soluble ou d'un de ses fragments comprenant le domaine extracellulaire D1 et D2 servant à moduler la réponse immunitaire. L'invention concerne aussi les vecteurs encodant les diverses formes des polypeptides LAG-3 mutés, des cellules hôtes produisant les polypeptides LAG-3 mutés, des méthodes de production permettant la récupération des polypeptides LAG-3 mutés, l'utilisations des polypeptides LAG-3 mutés dans la fabrication d'un composé pharmaceutique et de compositions pharmaceutiques comprenant les polypeptides LAG-3 mutés.
El Tayar Nabil
Huard Bertrand
Mastrangeli Renato
Triebel Frederic
Applied Research Systems Ars Holding N.v.
Fetherstonhaugh & Co.
Institut Gustave Roussy
Institut National de La Sante Et de La Recherche Medicale (inser
Merck Serono Sa
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