Mutants of the p4 protein of nontypable haemophilus...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/55 (2006.01) A61K 39/00 (2006.01) A61K 39/102 (2006.01) C07K 14/285 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 9/16 (2006.01) C12N 15/31 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2479118

A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.

L'invention concerne un variant de la protéine P4 qui présente une activité enzymatique réduite et qui induit la production d'anticorps dirigés contre la protéine P4 de type sauvage et/ou qui présente une bonne activité bactéricide contre H. influenzae non typable (NTHi) et qui peut être utilisé comme ingrédient actif dans une composition immunogène destinée aux humains. L'invention concerne également des méthodes d'utilisation de ces protéines, des compositions renfermant ces protéines, ainsi que des antigènes supplémentaires.

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