Mutants of the rb and p53 genes and uses thereof

Details Mutants of the rb and p53 genes and uses thereof Mutants of the rb and p53 genes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2170605

The present invention provides mutants of the Rb and p53 genes and methods utilizing these mutants therapeutically. Along with mutated Rb genes and p53 genes, the present invention provides plasmids containing a mutated Rb gene or a p53 gene. In addition, the present invention provides cells transfected with the plasmids of the present invention. Moreover, the present invention provides for methods of treating a variety of pathophysiological cell proliferative diseases.

Mutants des gènes Rb et p53 et procédés d'utilisation thérapeutique desdits mutants. Outre les gènes Rb et p53 que l'on a fait muter, la présente invention concerne des plasmides contenant un gène Rb ou p53 ayant muté. La présente invention concerne également des cellules transfectées à l'aide desdits plasmides. Enfin, la présente invention concerne des méthodes de traitement de toute une série de maladies à prolifération cellulaire pathophysiologique.

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