A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/55 (2006.01) C07K 14/81 (2006.01)
Patent
CA 2749772
The present invention relates to the use of a composition comprising of at least a mutated antithrombin - having an anticoagulant activity substantially reduced with respect to the anticoagulant activity of the non mutated antithrombin, or - having no anticoagulant activity, for the preparation of a drug intended for the prevention or the treatment of pathologies associated with cellular injury, such as infection, inflammation or hypoxic injury.
La présente invention concerne l'utilisation d'une composition comprenant au moins une antithrombine mutée présentant une activité anticoagulante sensiblement réduite par rapport à l'activité anticoagulante de l'antithrombine non mutée, ou ne présentant aucune activité anticoagulante, pour la préparation d'un médicament destiné à la prévention ou au traitement de pathologies associées à une lésion cellulaire, comme une infection, une inflammation ou une lésion hypoxique.
Bianchini Elsa
Borgel Born Botbol Delphine
Diehl Jean-Luc Rene
Ferger Born Picard Veronique
Lerolle Nicolas
Assistance Publique-Hopitaux de Paris
Goudreau Gage Dubuc
Universite Paris Descartes
Universite Paris Sud Xi
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