Mutated cyclin g1 protein

Details Mutated cyclin g1 protein Mutated cyclin g1 protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2401545

Methods of treating tumors, preventing restenosis, and treating hyperplasias, corneal haze, and cataracts by administering to an animal a mutated cyclin G1 protein. The mutated cyclin G1 protein may be administered to an animal by administering to an animal an expression vehicle, such as a retroviral vector comprising a gene construct encoding a mutated cyclin G1 protein.

L'invention concerne des méthodes permettant de traiter des tumeurs, de prévenir une resténose et de traiter une hyperplasie, une opacité cornéenne et des cataractes par l'administration d'une protéine cycline G1 mutée à un animal. Cette protéine peut être administrée à un animal par l'administration d'un véhicule d'expression, tel qu'un vecteur rétroviral renfermant un gène chimère codant pour une protéine cycline G1 mutée.

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