C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12P 13/04 (2006.01) C12P 17/10 (2006.01)
Patent
CA 2507225
By substituting an amino acid residue at least at one position participating in the efficient formation of (2R,4R)-monatin (100-position, 180- to 183- positions, 243-position and 244-position) in the amino acid sequence of wild type D-aminotransferase represented by SEQ ID NO:2 in Sequence Listing, the D- aminotransferase can be mutated so that it can efficiently produce (2R,4R)- monatin having an elevated sweetness from 4-(indol-3-ylmethyl)-4-hydroxy-2- oxoglutaric acid.
L'invention concerne la substitution d'un résidu d'acide aminé au moins en une position qui permet la formation efficace de (2R, 4R)-monatine (position 100, positions 180 à 183, position 243 et position 244) dans la séquence d'acide aminé de D-aminotransférase de type sauvage représentée par SEQ ID NO : 2 dans le listage de séquences. La D-aminotransférase peut être mutée afin de produire efficacement (2R, 4R)-monatine présentant un goût sucré élevé à partir de 4-(indol-3-ylmethyl)-4-hydroxy-2-acide glutarique.
Kashiwagi Tatsuki
Sugiyama Masakazu
Suzuki Ei-Ichiro
Watanabe Kunihiko
Ajinomoto Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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