Mutated e. coli heat-labile enterotoxin

Details Mutated e. coli heat-labile enterotoxin Mutated e. coli heat-labile enterotoxin

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61P 37/04 (2006.01) C07K 14/245 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2685495

This invention relates to a mutant E. coli heat-labile enterotoxin (LT) subunit A that can be used as an adjuvant. This subunit A mutant contains an amino acid substitution at a position corresponding to position 61 of a wild-type LT. An LT containing this mutated subunit A exhibits reduced toxicity compared to its wild type counterpart.

L'invention porte sur une sous-unité A d'entérotoxine thermolabile d'E. coli mutante (LT) qui peut être utilisée en tant qu'adjuvant. Cette sous-unité A mutante contient une substitution d'acide aminé à une position correspondant à la position 61 d'une LT de type sauvage. Une LT contenant cette sous-unité A mutée présente une toxicité réduite par comparaison avec son homologue de type sauvage.

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