C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2474885
The present invention relates to a mutated gene coding for a mutant LAT protein leading to an exaggerated TH2 differentiation. The invention relates to biological structures containing said mutant, particularly, non-human LAT gene mutated animals, plasmids, chromosomal DNA~s, embryos comprising said mutated gene, and applications thereof. The invention further relates to screening method for drug useful for treatment against asthma and allergy. Otherwise, the invention relates to method for producing IgE antibodies.
Cette invention concerne un gène muté codant une protéine LAT mutante donnant une différenciation T<SB>H</SB>2 exagérée. Cette invention concerne également des structures biologiques comprenant des animaux mutants, en particulier non humains, comprenant le gène muté LAT, des plasmides, des ADN chromosomiques et des embryons comprenant ce gène muté, ainsi que des applications associées. Cette invention concerne en outre des méthodes de criblage de médicaments utilisés dans le traitement de l'asthme et d'allergies. Cette invention concerne par ailleurs des méthodes de production d'anticorps IgE.
Aguado Vidal Enrique
Malissen Bernard
Malissen Marie
Institut National de La Sante Et de La Recherche Medicale (inser
Robic
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