Mutated hoxb4 proteins with improved stability, and methods...

Details Mutated hoxb4 proteins with improved stability, and methods... Mutated hoxb4 proteins with improved stability, and methods...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/02 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/34 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2590593

A polypeptide, the amino acid sequence of which comprises a sequence as set forth in Figure 15A (SEQ ID NO: *), including at least one mutation within the degron domain of the polypeptide encompassed between positions 1 and 35 of the sequence, wherein said at least one mutation reduces the susceptibility of the polypeptide to ubiquitin-proteasome degradation.

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