Mutated nonactivating igg2 domains and anti-cd3 antibodies...

Details Mutated nonactivating igg2 domains and anti-cd3 antibodies... Mutated nonactivating igg2 domains and anti-cd3 antibodies...

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2255826

The invention provides mutated IgG2 constant regions and anti-CD3 antibodies incorporating the same. Such antibodies specifically bind to the CD3 antigen on T-cells but induce reduced mitogenic response compared with otherwise identical antibodies bearing natural IgG2 constant regions. The antibodies can be used for treating disorders requiring immune suppression with fewer side effects than result from treatment with prior anti-CD3 antibodies.

L'invention concerne des régions constantes d'IgG2 mutantes et des anticorps anti-CD3 les comprenant. Lesdits anticorps se fixent spécifiquement à l'antigène CD3 sur les lymphocytes T mais induisent une réponse mitogénique réduite par rapport aux anticorps autrement identiques portant des régions constantes d'IgG2 naturelles. Lesdits anticorps peuvent être utilisés pour traiter les troubles nécessitant la suppression de la réaction immunitaire avec moins d'effets secondaires qu'avec les traitements antérieurs au moyen desdits anticorps anti-CD3 sus-mentionnés.

Affiliated with

Also associated with

Rating

Mutated nonactivating igg2 domains and anti-cd3 antibodies... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mutated nonactivating igg2 domains and anti-cd3 antibodies..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutated nonactivating igg2 domains and anti-cd3 antibodies... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1473718