C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/49 (2006.01) A61K 31/70 (2006.01) A61K 39/21 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C12N 7/01 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2216612
Mutated proteins coded by a mutated env gene of a lentivirus, particularly FIV, HIV or CAEV, peptide fragments contained in said mutated proteins and expression vectors expressing said mutated proteins as well as the applications thereof are described. The peptide fragments are contained in the principal immunodominant domain (PID) of the transmembrane protein (TM) of lentiviruses and particularly of feline immunodeficiency virus (FIV), human immunodeficiency virus (HIV-1 and HIV-2), arthritis virus and caprine encephalitis virus (CAEV), and are capable of modifying the immunogenic properties of the PID domain and of the Env protein of the lentiviruses containing them. Such fragments have one of the following sequences: SEQ ID N·1: CNQNQWLCK, SEQ ID N·2: CNQNQFLCK, SEQ ID N·3: CNQNQLWCK, SEQ ID N·4: CNQNQPFCK, SEQ ID N·5: CEHQHFFCK, SEQ ID N·6: CSMGTFFCK, SEQ ID N·7: CLTDSFFCK, SEQ ID N·8: CELKNFFCK, SEQ ID N·9: CRPAAFFCK, SEQ ID N·10: ELGCGSKLICKIP, SEQ ID N·11: IWGCNQNQFFCTTAVPWN, SEQ ID N·12: IWGVAFRQVCTTAVPW.
Protéines mutées, codées par un gène env muté de lentivirus, et notamment VIF, VIH ou CAEV, fragments peptidiques inclus dans lesdites protéines mutées, vecteurs d'expression exprimant lesdites protéines mutées ainsi que leurs applications. Lesdits fragments peptidiques sont inclus dans le domaine immunodominant principal (DIP) de la protéine transmembranaire (TM) des lentivirus et notamment du virus de l'immunodéficience féline (VIF), du virus de l'immunodéficience humaine (VIH-1 et VIH-2) et du virus de l'arthrite et de l'encéphalite caprine (CAEV), et sont aptes à modifier les propriétés immunogéniques du DIP et de la protéine Env de lentivirus les contenant. Ces fragments présentent notamment l'une des séquences suivantes: SEQ ID N·1; CNQNQWLCK, SEQ ID N·2: CNQNQFLCK, SEQ ID N·3: CNQNQLWCK, SEQ ID N·4: CNQNQPFCK, SEQ ID N·5: CEHQHFFCK, SEQ ID N·6: CSMGTFFCK, SEQ ID N·7: CLTDSFFCK, SEQ ID N·8: CELKNFFCK, SEQ ID N·9: CRPAAFFCK, SEQ ID N·10: ELGCSGKLICKIP, SEQ ID N·11: IWGCNQNQFFCTTAVPWN, SEQ ID N·12: IWGVAFRQVCTTAVPW.
Pancino Gianfranco
Sonigo Pierre
Borden Ladner Gervais Llp
Centre National de La Recherche Scientifique
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