C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/195 (2006.01) C07K 14/21 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2616987
The invention provides mutated Pseudomonas exotoxins (PE) that have reduced immunogenicity compared to PEs containing the native sequence. The PEs of the invention have one or more individual mutations of positions of the native sequence of PE that reduce antibody binding to one or more PE epitopes. Nucleic acids encoding the mutated PEs, chimeric molecules comprising them, compositions comprising the chimeric molecules and methods of using them, are also provided.
L'invention concerne des exotoxines de Pseudomonas (PE) qu'ils présentent une immunologie initie des réduite par rapport aux PE contenant la séquence native. Les PE de l'invention possèdent une ou plusieurs mutations individuelles de positions de la séquence native de PE qui réduit la liaison d'anticorps à un ou plusieurs épitopes PE. L'invention concerne également des acides nucléiques codant les PE mutés, des molécules chimères les contenant, des compositions contenant ces molécules chimères et des procédés d'utilisation de ceux-ci.
Fitzgerald David
Kreitman Robert
Lee Byungkook
Nagata Satoshi
Onda Masanori
Fetherstonhaugh & Co.
The Government Of The United States Of America As Represented By The Se Cretary Of Health And Human Services
LandOfFree
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