C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/72 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/16 (2006.01) C12N 15/63 (2006.01) C12N 15/82 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2135644
The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch for regulating expression in gene therapy.
Mcdonnell Donald P.
O'malley Bert W.
Schrader William T.
Tsai Ming-Jer
Vegeto Elisabetta
Baylor College Of Medicine
Smart & Biggar
LandOfFree
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