Mutation assays involving blood cells that metabolize toxic...

Details Mutation assays involving blood cells that metabolize toxic... Mutation assays involving blood cells that metabolize toxic...

C - Chemistry, Metallurgy

12

N

167/37, 195/34.7

C12N 5/02 (2006.01) C12Q 1/18 (2006.01) G01N 33/50 (2006.01)

Patent

CA 1212643

-45- MUTATION ASSAYS INVOLVING BLOOD CELLS THAT METABOLIZE TOXIC SUBSTANCES Abstract A line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity) is disclosed. Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. Mutation assays using these cells, and other cells with similar characteristics, are also disclosed.

432646

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