Mutation of mec-1 related genes in the treatment of disease

Details Mutation of mec-1 related genes in the treatment of disease Mutation of mec-1 related genes in the treatment of disease

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/7052 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2380624

The present invention relates to composition and methods of identifying one or more secondary drug targets and their use in the identification of drugs or drug candidates, particularly for the treatment of cancer or cell replication disorders. The yeast-based synthetic lethal screens are used to functionally identify and validate new gene targets to kill cells with defects in cell cycle pathways. These newly identified gene targets can be used to develop new therapeutics to treat cancer, benign cell growth, and yeast infections. 51

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