Mutations in erb2 associated with cancerous phenotypes

Details Mutations in erb2 associated with cancerous phenotypes Mutations in erb2 associated with cancerous phenotypes

C - Chemistry, Metallurgy

07

K

C07K 14/71 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2575462

The invention relates to mutations in ErbB2 gene products. The mutations described are identified in human tumours of natural origin. These mutations are associated with cancerous phenotypes and can be used as a basis for the diagnosis of cancer, cancerous cells or a predisposition to cancer in human subjects, selection of appropriate anti-cancer therapy and the development of anti-cancer therapeutics.

L'invention concerne des mutations dans des produits géniques ErbB2. Les mutations décrites sont identifiées dans des tumeurs humaines d'origine naturelle. Ces mutations sont associées à des phénotypes cancéreux et peuvent être utilisées comme base pour le diagnostic du cancer, de cellules cancéreuses ou d'une prédisposition au cancer chez des sujets humains, et pour la sélection d'un traitement anticancéreux approprié et le développement de traitements anticancéreux.

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