Mutations in the bcr-abl tyrosine kinase associated with...

Details Mutations in the bcr-abl tyrosine kinase associated with... Mutations in the bcr-abl tyrosine kinase associated with...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01) C07K 14/82 (2006.01) C40B 30/04 (2006.01)

Patent

CA 2753372

The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T3151 Bcr-Ab1), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.

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