C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 15/52 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2415350
The invention relates to a DNA sequence, which codes for a mutant of the bacteriophage P1 recombinase, in which a particular cryptic splicing site is disabled by means of a base mutation which alters the Cre protein sequence. The invention further relates to a DNA sequence which codes for a fusion protein from the named Cre mutants and a ligand-binding domain of a receptor protein. The invention furthermore relates to vectors, micro-organisms and transgenic organisms, containing such a DNA sequence and Cre mutants or Cre fusion proteins which are coded by said DNA sequence.
La présente invention concerne une séquence d'ADN codant pour un mutant de la recombinase du bactériophage P1, dans laquelle un site cryptique d'épissage spécial est désactivé par le biais d'une mutation de la base modifiant la séquence de protéines Cre, ainsi qu'une séquence d'ADN codant pour une protéine hybride des mutants Cre mentionnés et d'un domaine de liaison aux ligands d'une protéine réceptrice. L'invention concerne également des vecteurs, micro-organismes et organismes transgéniques, contenant une telle séquence d'ADN, ainsi que des mutants Cre ou protéines hybrides Cre codés par lesdites séquences d'ADN.
Edenhofer Frank Oliver Stefan
Rajewsky Klaus
Wunderlich Thomas
Artemis Pharmaceuticals Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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