Mutein of a bone morphogenetic protein and use thereof

Details Mutein of a bone morphogenetic protein and use thereof Mutein of a bone morphogenetic protein and use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/51 (2006.01) A61K 38/18 (2006.01) C07K 14/47 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2557788

The present invention is related to a mutein of a bone morphogenetic protein, whereby the mutein comprises an amino acid substitution compared to the wildtype of the bone morphogenetic protein at the amino acid position corresponding to amino acid position 51 of human BMP-2.

L'invention concerne une mutéine d'une protéine morphogénétique osseuse. En comparaison avec le type sauvage de la protéine morphogénétique osseuse, cette mutéine comprend une substitution d'acide aminé au niveau de la position de l'acide aminé correspondant à la position d'acide aminé 51 de la BMP-2 humaine.

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