Muteins of fibroblast growth factor 21

Details Muteins of fibroblast growth factor 21 Muteins of fibroblast growth factor 21

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) C12N 1/19 (2006.01)

Patent

CA 2549249

The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.

L'invention concerne de nouvelles mutéines du facteur de croissance fibroplastique humain 21 à propriétés pharmaceutiques améliorées, ainsi que des protéines et des espèces d'acide nucléique de codage respectives. L'invention concerne également des vecteurs et des cellules hôtes destinées à la propagation de ces séquences d'acide nucléique et à la production de ces mutéines. L'invention concerne enfin des procédés de traitement du diabète de type 2, de l'obésité, du syndrome métabolique, et permet également de réduire la mortalité et la morbilité de patients gravement malades.

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