C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 51/08 (2006.01)
Patent
CA 2729322
The present invention relates to novel muteins derived from human lipocalin 2(hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also relates to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.
La présente invention concerne de nouvelles mutéines dérivées de lipocaline 2 humaine (hnGAL) et des protéines associées qui se lient à un ligand non naturel donné avec une affinité détectable. Linvention concerne en outre des molécules dacide nucléique correspondantes codant pour une telle mutéine et un procédé pour leur génération. Linvention concerne en outre un procédé pour produire une telle mutéine. De plus, linvention concerne une composition pharmaceutique comprenant une telle mutéine de lipocaline ainsi que différentes utilisations de la mutéine.
Eichinger Andreas
Kim Hyun-Jin
Skerra Arne
Blake Cassels & Graydon Llp
Technische Universitaet Munchen
LandOfFree
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