Muteins of hypoxia inducible factor alpha and methods of use...

Details Muteins of hypoxia inducible factor alpha and methods of use... Muteins of hypoxia inducible factor alpha and methods of use...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/02 (2006.01) A61K 38/17 (2006.01) A61K 38/44 (2006.01) A61K 48/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12N 15/74 (2006.01) C12N 15/85 (2006.01) C12Q 1/26 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2441510

The present invention provides hypoxia inducible factor alpha muteins, DNA sequences encoding these hypoxia inducible factor alpha muteins, recombinant DNA molecules containing those DNA sequences operatively linked to expression control sequences and capable of inducing expression of an hypoxia inducible factor alpha muteins, hosts transformed with those recombinant DNA molecules, pharmaceutical compositions containing hypoxia inducible factor alpha muteins and methods of using those compositions to treat hypoxia and ischemic related tissue damage.

L'invention concerne des mutéines du facteur alpha inductible en hypoxie, des séquences d'ADN codant pour lesdites mutéines du facteur alpha inductible en hypoxie, des molécules d'ADN recombinées contenant lesdites séquences d'ADN liées activement à des séquences de régulation d'expression et capables d'induire l'expression de mutéines du facteur alpha inductible en hypoxie, des hôtes transformés à l'aide desdites molécules d'ADN recombinées, des préparations pharmaceutiques contenant lesdites mutéines du facteur alpha inductible en hypoxie et des procédés d'utilisation desdites préparations pour le traitement de l'hypoxie et de lésions tissulaires d'origine ischémique.

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