Muteins of tear lipocalin and methods for obtaining the same

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/435 (2006.01)

Patent

CA 2659413

The present invention relates to novel muteins derived from human tear lipocalin. The invention also refers to a corresponding nucleic acid molecule encoding such a mutein and to a method for its generation. The invention further refers to a method for producing such a mutein. Finally, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.

La présente invention concerne de nouvelles mutéines dérivées de lipocaline lacrymale humaine. L'invention concerne également une molécule d'acide nucléique correspondante codant pour une telle mutéine, et un procédé permettant de la produire. L'invention concerne en outre un procédé de production d'une telle mutéine. Enfin, l'invention concerne une composition pharmaceutique comprenant une telle mutéine de lipocaline, ainsi que diverses utilisations de la mutéine.

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