C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01)
Patent
CA 2713557
The present invention relates to novel muteins derived from human tear lipocalin having affinity to human c-Met receptor tyrosin kinase (c-Met). The invention also refers to a corresponding nucleic acid molecule encoding such a mutein and to a method for its generation. The invention further refers to a method for producing such a mutein. Finally, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.
La présente invention concerne de nouvelles mutéines dérivées de lipocaline de larmes humaines ayant une affinité pour le récepteur tyrosine kinase c-Met humain (c-Met). L'invention concerne également une molécule d'acide nucléique correspondante codant pour une telle mutéine et un procédé pour sa génération. L'invention concerne en outre un procédé de production d'une telle mutéine. L'invention concerne enfin une composition pharmaceutique comprenant une telle mutéine de lipocaline, ainsi que différentes utilisations de la mutéine.
Hohlbaum Andreas
Huelsmeyer Martin
Matschiner Gabriele
Trentmann Stefan
Borden Ladner Gervais Llp
Pieris Ag
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