Muteins of the cgrp 1-7 peptide fragment and use thereof as...

Details Muteins of the cgrp 1-7 peptide fragment and use thereof as... Muteins of the cgrp 1-7 peptide fragment and use thereof as...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2420504

Muteins of the Ser-Cys-Asn-Thr-Ala-Thr-Cys sequence from the N-terminal 1-7 fragment of the CGRP peptide, possessing an enhancing action on the activation of neuronal nicotinic receptors, their pharmaceutical compositions containing the same and their use for the potential therapy of neurological diseases are described.

L'invention concerne des mutéines de la séquence Ser-Cys-Asn-Thr-Ala-Thr-Cys du fragment N-terminal 1-7 du peptide CGRP, lesquelles mutéines exercent une action d'amplification de l'activation des récepteurs nicotiniques neuronaux. L'invention concerne également les compositions pharmaceutiques contenant lesdites mutéines et leur utilisation pour un traitement potentiel de maladies neurologiques.

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