Muteins of the granulocyte colony stimulating factor (g-csf)

Details Muteins of the granulocyte colony stimulating factor (g-csf) Muteins of the granulocyte colony stimulating factor (g-csf)

C - Chemistry, Metallurgy

12

N

C12N 15/27 (2006.01) A61K 38/19 (2006.01) B23K 26/00 (2006.01) C07K 14/535 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2041439

A b s t r a c t A granulocyte stimulating factor (G-CSF) or a G-CSF variant differs from natural G-CSF in that one or several amino acids of the sequence 51 52 53 54 55 56 Leu-Gly-His-Ser-Leu-Gly-Ile at position 50 to 56 of the mature G-CSF with 174 amino acids or at position 53 to 59 of the mature G-CSF with 177 amino acids or/and at least one of the 4 His residues at position 43, 79, 156 or 170 of the mature G-CSF with 174 amino acids or at position 46, 82, 159 or 173 of the mature G-CSF with 177 amino acids are mutagenized. It is suitable for immunotherapy.

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