Mutilin derivatives and their use as pharmaceutical

Details Mutilin derivatives and their use as pharmaceutical Mutilin derivatives and their use as pharmaceutical

C - Chemistry, Metallurgy

07

C

C07C 323/52 (2006.01) A61K 31/22 (2006.01) A61K 31/4168 (2006.01) A61K 31/495 (2006.01) A61K 31/5375 (2006.01) A61P 31/04 (2006.01) C07D 233/48 (2006.01) C07D 295/088 (2006.01) C07D 295/215 (2006.01) C07D 307/52 (2006.01)

Patent

CA 2635950

14-0-[(((C1.6)Alkoxy-(C1.6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O- [(((C1-6)Mono- or dialkylamino-(C1.6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Hydroxy-(C1-6)-alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Formyl- (C0.5)-alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Guanidino-imino-(C1- 6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Ureido-imino-(C1-6)alky)- phenylsulfany]-acety]-mutilins, 14-O-[((Thioureido-imino-(C1-6)alkyl)- phenylsulfanyl)-acetyl]-mutilins, 14-O-[((lsothioureido-imino-(C1-6)alkyl)- phenylsulfanyl)-acetyl]-mutilins and their use as pharmaceuticals.

La présente invention a pour objet les 14-O-[(((C1.6)alcoxy-(C1.6)alkyl)-phénylsulfanyl)-acétyl]-mutilines, les 14-O-[(((C1-6)mono- ou dialkylamino-(C1.6)alkyl)-phénylsulfanyl)-acétyl]-mutilines, les 14-O-[((hydroxy-(C1-6)-alkyl)-phénylsulfanyl)-acétyl]-mutilines, les 14-O-[((formyl-(C0.5)-alkyl)-phénylsulfanyl)-acétyl]-mutilines, les 14-O-[((guanidino-imino-(C1-6)alkyl)-phénylsulfanyl)-acétyl]-mutilines, les 14-O-[((uréido-imino-(C1-6)alky)-phénylsulfany]-acétyl]-mutilines, les 14-O-[((thiouréido-imino-(C1-6)alkyl)-phénylsulfanyl)-acétyl]-mutilines, les 14-O-[((isothiouréido-imino-(C1-6)alkyl)-phénylsulfanyl)-acétyl]-mutilines et leur emploi en tant que substances pharmaceutiques.

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