C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/195 (2006.01) A61K 38/16 (2006.01) A61P 31/12 (2006.01)
Patent
CA 2558976
The present invention relates, e.g., to an isolated polypeptide from a cyanobacterium, Microcystis viridis, which binds specifically to an oligosaccharide comprising the tetrasaccharide Man-alpha-(1.fwdarw.6)Man-beta (1.fwdarw.4) G1cNAc-beta(1.fwdarw.4)G1cNAc. The polypeptide can be obtained, for example, from a cell that expresses a recombinant nucleic acid that encodes a MVL-like polypeptide. The invention also relates to an isolated polypeptide comprising one or more copies of the sequence GPLWSNXEAQXXGPX (SEQ ID NO: 1) and/or one or more copies of the sequence FTGQWXTXVEXXMSV (SEQ ID NO: 2), wherein the polypeptide binds specifically to the above-mentioned oligosaccharide. Conjugates comprising such polypeptides and an effector molecule are also disclosed, as are methods of using such polypeptides or conjugates, e.g., for inhibiting infection by a virus, such as HIV, or for removing a virus, such as HIV, from a sample, such as a bodily fluid or an inanimate object.
La présente invention concerne entre autres un polypeptide isolé issu d'une cyanobactérie, Microcystis viridis, qui se lie de manière spécifique à un oligosaccharide comprenant le tétrasaccharide Man-alpha-(1?6)Man-béta (1?4) GlcNAc-béta(1?4)GlcNAc. Le polypeptide peut être obtenu, par exemple, à partir d'une cellule qui exprime un acide nucléique de recombinaison codant un polypeptide de type MVL. La présente invention concerne également un polypeptide isolé qui comprend une ou plusieurs copies de la séquence GPLWSNXEAQXXGPX (SEQ ID NO: 1) et/ou une ou plusieurs copies de la séquence FTGQWXTXVEXXMSV (SEQ ID NO: 2), ce polypeptide se liant de manière spécifique audit oligosaccharide. En outre, cette invention concerne des conjugués comprenant de tels polypeptides et une molécule effectrice, ainsi que des procédés pour utiliser ces polypeptides ou conjugués, par exemple pour inhiber une infection par un virus, telle que le VIH, ou pour éliminer un virus, tel que le VIH, à partir d'un échantillon, tel qu'un fluide corporel ou un objet inanimé.
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Smart & Biggar
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