Mycer immortalized hepatocyte

Details Mycer immortalized hepatocyte Mycer immortalized hepatocyte

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2581091

The invention relates to the production of hepatocyte cell lines useful in toxicology screens or therapy. A mammalian hepatocyte comprises, as a single polypeptide, a fusion protein comprising a c-myc protein and an oestrogen receptor, or functional fragments thereof.

La présente invention a pour objet la production de lignées cellulaires d~hépatocytes utilisées dans le cadre de criblages toxicologiques ou de thérapies. Un hépatocyte de mammifère selon la présente invention comprend, en tant que polypeptide unique, une protéine de fusion constituée d~une protéine c-myc et d~un récepteur d~AEstrogène, ou de fragments fonctionnels de ces deux constituants.

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