C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
150/16, 167/44,
C12Q 1/04 (2006.01) C12P 1/06 (2006.01) C12Q 1/18 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01)
Patent
CA 1163193
ABSTRACT A method for detecting the presence of Mycobacteria in a fluid or tissue which comprises mixing the fluid or tissue containing a secretory product of Mycobacteria with a complex of a tracer-containing molecule and a binding macromolecule having reversible binding affinity for the tracer-containing molecule and detecting the tracer-containing molecule, wherein the tracer-containing molecule is a charcoal-adsorbable protein from Mycobacterium tuberculosis which has a molecular weight of 20,000-30,000 and which is immunochemically stable from 4°C to 250°C and has a pH range from 3.0 to 9Ø The method is particularly applicable to the detection of infectious tuberculosis in humans and determining the antibiotic sensitivity of infecting Mycobacteria.
376818
Moffat & Co.
Montefiore Hospital And Medical Center
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