Mycobacteria with mannose cap-deficient lipoarabinomannan

Details Mycobacteria with mannose cap-deficient lipoarabinomannan Mycobacteria with mannose cap-deficient lipoarabinomannan

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 39/04 (2006.01) C12N 1/21 (2006.01) C12N 9/10 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2595074

The present invention relates to mycobacterial lipoarabinomannan cap-specific mannosyl transferases and nucleic acid encoding such transferases. The invention further relates to Mycobacteria in which the lipoarabinomannan cap- specific mannosyl transferases have been inactivated and that therefore express mannose cap-deficient lipoarabinomannan. Such Mycobacteria with mannose cap-deficient lipoarabinomannan may be used as more effective vaccines against mycobacterial diseases as they lack the immunosuppressive action of the mannose cap.

L'invention concerne des transférases mycobactériennes de mannosyle spécifique à des coiffes de lipoarabinomannane et un acide nucléique codant de telles transférases. L'invention concerne également des mycobactéries dans lesquelles les transférases de mannosyle spécifique à des coiffes de lipoarabinomannane ont été inactivées et par conséquent qui expriment du lipoarabinomannane déficient en coiffes de mannose. De telles bactéries présentant lipoarabinomannane déficient en coiffes de mannose peuvent être utilisées en tant que vaccins efficaces contre des maladies mycobactériennes, puisqu'elles ne présentent pas l'action immunosuppressive des coiffes de mannose.

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