Mycobacterial disease detection, treatment, and drug discovery

Details Mycobacterial disease detection, treatment, and drug discovery Mycobacterial disease detection, treatment, and drug discovery

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/00 (2006.01) C07K 14/195 (2006.01)

Patent

CA 2644338

Methods for detecting and treating Mycobacterium-related diseases including reducing Mycobacterial virulence, reducing RV3133c dimerization, and treating a subject with a Mycobacterial infection using identified compounds are disclosed. Examples of compounds useful in the treatment of Mycobacterium-related diseases include N-(4-[(acetylamino)sulfonyl]phenyl)-3-phenylpropanamide; 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1yl)ethanone hydrochloride; and 1-(1,3-benzoxazol-2-yl)-3-({4-[(2-hydroxyethyl)sulfonyl]phenyl}amino)acrylaldehyde. Further disclosed are methods for identifying agents that interact with a polypeptide in a Mycobacterium cell.

L'invention concerne des procédés pour détecter et traiter des maladies liées aux mycobactéries comprenant la réduction de la virulence mycobacrérienne, la réduction de la dimérisation de RV3133c, et le traitement d'un sujet souffrant d'une infection mycobactérienne au moyen des composés identifiés. N-(4-[(acétylamino)sulfonyl]phényl)-3-phénylpropanamide; l'hydrochlorure de 1-(3,5-di-tert-butyl-4-hydroxyphényl)-2-(2-imino-3-méthyl-2,3-dihydro-1H-benzimidazol-1yl)éthanone; et 1-(1,3-benzoxazol-2-yl)-3-({4-[(2-hydroxyéthyl)sulfonyl]phényl}amino)acrylaldéhyde sont des exemples des composés utilisés dans le traitement des maladies liées aux mycobactéries. L'invention concerne, de plus, des procédés permettant l'identification d'agents qui entrent en interaction avec un polypeptide dans une cellule de la mycobactérie.

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