Mycobacterium vaccae for down-regulation of the th2 activity...

A - Human Necessities – 61 – K

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A61K 35/74 (2006.01) A61P 37/02 (2006.01) A61K 39/02 (2006.01)

Patent

CA 2273848

Antigenic and/or immunogenic material derived from Mycobacterium vaccae is used to down-regulate Th2 activity of the immune system without up-regulation of Th1 activity. Disorders such as Chronic Fatigue Syndrome, Gulf War Syndrome and Total Allergy Syndrome are treated. The material preferably comprises dead M. vaccae cells in a composition which does not include a non-M. vaccae antigen, immunogen or allergen.

La présente invention se rapporte à l'utilisation d'un matériel antigénique et/ou immunogénique dérivé de Mycobacterium vaccae pour réguler négativement l'activité Th2 du système immunitaire sans réguler positivement l'activité Th1. La présente invention permet de traiter des troubles tels que le syndrome de fatigue chronique, le syndrome de la guerre du Golfe et le syndrome d'allergie total. Le matériel comprend de préférence des cellules de Mycobacterium vaccae mortes dans une composition ne contenant pas d'antigène, d'immunogène ou d'allergène non Mycobacterium vaccae.

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