Mycophenolate mofetil in association with peg-ifn-.alpha.

Details Mycophenolate mofetil in association with peg-ifn-.alpha. Mycophenolate mofetil in association with peg-ifn-.alpha.

A - Human Necessities

61

K

A61K 38/21 (2006.01) A61K 31/343 (2006.01) A61K 31/5377 (2006.01) A61K 47/48 (2006.01) A61P 1/16 (2006.01) A61P 31/12 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2380653

The use of therapeutically effective amount of IFN- .alpha. or PEG-IFN-.alpha. in association with a therapeutically effective amount of a pharmaceutically acceptable salt or prodrug of mycophenolic acid for the manufacture of medicaments for treating liver diseases patients. The components are administered over a period of time at least sufficient to reduce the amount of HCV-RNA present in the peripheral blood of said patient to less than 100 copies/ml at 24 weeks after the end of treatment.

L'invention concerne l'utilisation d'une quantité thérapeutiquement efficace de IFN-? associée à une quantité thérapeutiquement efficace d'un sel pharmaceutiquement acceptable ou promédicament d'acide mycophénolique, en vue de fabriquer des médicaments permettant de traiter des patients atteints d'affections hépatiques. Les composants sont administrés pendant une période de temps au moins assez longue pour réduire la quantité de HCV-RNA présente dans le sang périphérique desdits patients à moins de 100 copies/ml au bout de 24 semaines après la fin du traitement.

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