A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) A61K 39/04 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2457514
The present invention provides a reproducible M. bovis challenge model and methods for reliably inducing and establishing a disease or disorder caused by infection with M. bovis by administering to an animal an effective amount of a M. bovis culture. The challenge culture of the present invention is administered in an amount sufficient to elicit M. bovis specific cellular or humoral immune responses. The M. bovis challenge model in accordance with the present invention can be used to evaluate the efficacy of potential vaccines.
L'invention concerne un modèle d'essai de M. bovis reproductible, ainsi que des méthodes permettant d'induire et d'établir de manière fiable une maladie ou un trouble provoqué par une infection associée à M. bovis, par le biais de l'administration, à un animal, d'une dose efficace d'une culture de M. bovis. La culture d'essai de l'invention est administrée en quantité suffisante pour éliciter des réponses immunitaires cellulaires ou humorales spécifiques de M. bovis. Le modèle d'essai de M. bovis de l'invention peut être utilisé pour évaluer l'efficacité de vaccins potentiels.
Keich Robin Lee
Stipkovits Laszlo Pal
Pfizer Products Inc.
Smart & Biggar
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