C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 5/078 (2006.01) C07K 7/02 (2006.01) C07K 14/715 (2006.01)
Patent
CA 2590750
The present invention relates to peptidic and peptidomimetic compounds with the formula (X-) AA1-AA2-AA3-AA4-AA5-AA6-AA7 in which the various groups are defined in the description here below, which mimic a particular protein portion of MyD88, preventing its homodimerisation and interfering with its interaction with the TIR domain. The present invention also provides procedures for the preparation of said compounds, pharmaceutical compositions containing them and their use as medicaments, particularly for the treatment of inflammatory and autoimmune diseases.
La présente invention concerne des composés peptidiques et peptidomimétiques de la formule (X-) AA1-AA2-AA3-AA4-AA5-AA6-AA7, dans laquelle les divers groupes sont tels que définis dans le mémorandum descriptif, et qui imitent une partie protéique particulière de MyD88 empêchant ainsi son homodimérisation et interférant dans son interaction avec le domaine TIR. L'invention concerne également des procédures destinées à la préparation desdits composés, des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés comme médicaments, en particulier pour le traitement de maladies inflammatoires ou autoimmunes.
Carminati Paolo
Fanto Nicola
Gallo Grazia
Mastroianni Domenico
Ruggiero Vito
Fetherstonhaugh & Co.
Sigma-Tau Industrie Farmaceutiche Riunite S.p.a.
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