Myelin basic protein peptides and uses thereof

Details Myelin basic protein peptides and uses thereof Myelin basic protein peptides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 5/08 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2330826

This invention pertains generally to the treatment of autoimmune diseases of the central nervous system characterized by demyelination. In particular, this invention pertains to novel peptides derived from human myelin basic protein (MBP). When complexed with the appropriate major histocompatibility complex (MHC) molecule, these peptides can be used to treat multiple sclerosis and other demyelinating autoimmune diseases.

L'invention a trait de manière générale au traitement de maladies auto-immunes du système nerveux central caractérisées par une démyélinisation. En particulier, l'invention a trait à de nouveaux peptides dérivés de la protéine basique de myéline (MBP) humaine. Lorsqu'ils forment des complexes avec une molécule appropriée du complexe majeur d'histocompatibilité (CMH), ces peptides peuvent être utilisés pour traiter la sclérose en plaques et d'autres maladies auto-immunes démyélinisantes.

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