Myelopeptides and their therapeutic use

Details Myelopeptides and their therapeutic use Myelopeptides and their therapeutic use

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 5/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2274731

A peptide comprising 4 to 10 amino acids including X1-Pro, Pro-X2 or X1-Pro- X2, wherein X1 and X2 are independently selected from Lys, Arg, His, Asp, Glu, Asn and Gln, and the other amino acids are independently selected from Gly, Ala, Val, Leu, Ile, Nle, Nva, Pro, Phe, Tyr, Trp, Cys, Met, Ser and Thr. Such peptides, including LVCYPQ, FRPRIMTP, VVYPD and VDPP, obtainable from porcine bone marrow cell culture, having immunostimulating and anti-viral properties.

La présente invention a trait à un peptide renfermant entre 4 et 10 acides aminés comprenant X?1¿-pro, Pro-X?2¿ ou X?1¿-pro-X ?2¿, où X?1¿ et X?2¿ sont sélectionnés indépendamment à partir de lys, Arg, His, Asp, Glu, Asn et Gln. Les autres acides aminés sont sélectionnés indépendamment à partir de Gly, Ala, Val, Leu, Ile, Nle, Nva, Pro, Phe, Tyr, Trp, Cys, Met, Ser et Thr. De tels peptides, y compris LVCYPQ, FRPRIMTP, VVYPD et VDPP, qu'on peut obtenir à partir d'une culture de cellules porcines médullaires, possèdent des propriétés immunostimulantes et antivirales.

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